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Competitive advantage
- Long-term experience in animal models of nervous system damage, such as peripheral neuropathy and multiple sclerosis (MS)
- Expertise in in vitro culturing systems of whole dorsal root ganglion explants, dissociated sensory neurons, microglia and T cells
- Expertise in using anti-inflammatory mediators and immune cell therapies in vivo
- Capacity to perform immunotherapies in animal models
Impact
- Testing neuroprotective candidate drugs for the treatment of peripheral neuropathy
- Developing novel immunotherapeutic approaches for the treatment of neurological disorders and neuropathic pain
Successful outcomes
- Identified neuroimmune responses in neuropathic pain caused by peripheral nerve injury, autoimmune diseases such as MS, and chemotherapy-induced peripheral neuropathy
- Tested multiple drug candidates for the treatment of peripheral neuropathy in vitro and in vivo
- Developed adoptive cell therapy in pre-clinical models of MS and neuropathic pain
Capabilities and facilities
- A range of behavioural assays, animal surgery, and primary cell culture setups for the assessment of neurological disease/ pain states
- A range of molecular and biochemical assays for the assessment of neuroinflammation in blood/tissues
Our partners
- Multiple national and international collaborations with researchers and clinicians at universities and hospitals
- Relationship with various industry partners (successfully completed several research contracts)